Synvichor™
Synvichor is the world’s first genomic PCR test that sets a new medical standard globally for the rapid, accurate and reliable differentiation of joint pain.
Undifferentiated joint pain: a global problem
When a patient presents with a red, hot, swollen and painful joint, reliably differentiating infection from inflammation poses a significant global problem.
Typical wait times for culture results vary from 24hrs to 21 days, with a true positivity of up to 20%, meaning they are inconclusive more than 80% of the time.
Rather than risk missing or misdiagnosing an infection, the current approach sees the patient admitted to hospital and treated with antibiotics.
This results in uncertainty for patients and clinicians, increased costs to the hospital, and poorer outcomes.
Unparalleled speed, precision, and reliability
With up to 95% negative and positive predictive value and results in ~3 hours, Synvichor provides rapid and reliable differentiation of joint pain.
Synvichor helps to rapidly assess which patients require urgent treatment for infection, and which patients can be safely managed in the community for non-infectious inflammation.
Enhances your diagnostic speed
Optimises your treatment options
Enables clinicians to safely manage up to two-thirds of patients in the community
RAPID RESULTS
~ 3 hours
vs current culture testing
24 hours - 21 days
RELIABLE PRECISION
UP TO
95%
ACCURACY
vs current culture testing
13-20% accuracy[1]
2. Graue C et al. Open Forum Infect Dis. 2020; 7(Suppl 1):S233–4.
Synvichor sets a new global medical standard that enhances surgeon’s treatment options, improves outcomes for patients, and reduces the burden on the hospital system.
Synvichor has been designed to fit into your existing testing and work-up routine for all patients with undifferentiated joint pain.
Synvichor has the potential to deliver billion-dollar savings to the healthcare system annually and significantly increase hospital bed day capacity per year.
Enhances surgeons’ treatment decisions
- Rapid and accurate diagnosis, without any additional effort to the existing testing and work-up routine for undifferentiated joint pain
- Faster differentiation of joint pain
- Reduces overtreatment with antibiotics
- Optimises clinical and patient outcomes
- Increases confidence to initiate optimal treatment plan
Improves patient outcomes
- Rapid and accurate diagnosis provides patients clarity about their condition and confidence in their treatment
- Optimises clinical and quality of life outcomes
- Reduces risk of complications
- Reduces overuse of antibiotics and avoids over/under treatment
- Patients get home faster
Reduces the burden on hospitals
- Up to 65% fewer admissions for non-infectious patients
- Potential to increase hospital capacity by over 100,000 bed days per year
- Potential to reduce average length of stay for infections
- Ability to increase elective surgery procedures
- Allows hospitals to receive correct reimbursement for patient care, adding ~$700m in revenue for an additional 25,000 patients.
Synvichor™ Frequently Asked Questions
What equipment do I need to use Synvichor?
Our all-in-one solution, HighPlex, is an automated PCR lab in a box. This device can extract, amplify and analyse synovial fluid samples directly from the patient. With our unique signature and algorithmic combination, we can provide the clinician with actionable information in as little as three hours.
I don’t have a Highplex device, how do I get one?
Reach out to our team to ask how we can place a device in your laboratory.
Can I run the Synvichor test on another machine?
Synvichor can only be run on the HighPlex device. The unique combination of MT-PCR (probeless PCR) and our genomic signature has been optimised to deliver the high precision and quality results of Synvichor.
How do I use Synvichor?
Simply take a synovial aspirate from your patient, fill in a request form, and send it to the laboratory. Once there, lab staff take a small aliquot of synovial fluid (less than 0.5mL) and load it into the HighPlex device. Results are delivered to your preferred pathology viewer as soon as they are complete.
How accurate is the Synvichor test?
Synvichor technology offers unparalleled accuracy in both negative and positive predictive value (NPV, PPV). We achieve this by using multiple cut-off thresholds to enhance the performance of our unique interpretive algorithm.
Based on a cohort of over 300 patients, we offer the following threshold values:
Score 1: NPV >95%
Score 2: NPV >87%
Score 3: PPV >77%
Score 4: PPV >95%
Is there any change to the existing work-up?
Synvichor has been designed to fit into the existing testing and work-up routine for all patients with undifferentiated joint pain. The only change will be the test you order (Synvichor Native for native joints or Synvichor Prosthetic for prosthetic joints). Laboratory staff take a small aliquot of synovial fluid (less than 0.5mL) and place this into the HighPlex PCR device. The rest of the process is fully automated, providing results in three hours.
How do I interpret the result?
Using the probability scores:
Score 1: Extremely unlikely to be infected: safest group for discharge.
Score 2: Unlikely to be infected: consider other tests before discharge.
Score 3: Likely to be infected: probable admission with further testing.
Score 4: Extremely likely to be infected: consider commencing treatment options.
How do I run the Synvichor test?
Simply take a synovial aspirate from your patient, fill in a request form, and send it to the laboratory. Once there, lab staff take a small aliquot of synovial fluid (less than 0.5mL) and load it into the HighPlex device. The HighPlex device then completes extraction, amplification and analysis, delivering accurate reliable and actionable results to the clinician in three hours.
Revolution Surgical Pty Ltd
5/14-16 Crescent Street, Rozelle NSW 2039 AU
ABN: 63 165 643 434
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